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Journal Article 1

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2023 1

Keywords

ADAM10 inhibitor 1

Barrier disruption 1

Host-directed therapy 1

Kaempferol 1

Necroptosis 1

Staphylococcus aureus infection 1

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Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureus Infection Article

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Engineering 2023, Volume 28, Issue 9,   Pages 206-221 doi: 10.1016/j.eng.2023.03.006

Abstract: Our study is the first to demonstrate the indispensable role of ADAM10 in S. aureus-induced necroptosisprotected mice from S. aureus infection by suppressing Hla-mediated barrier disruption and necroptosis

Keywords： Host-directed therapy     Kaempferol     ADAM10 inhibitor     Staphylococcus aureus infection     Barrier disruption     Necroptosis    

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Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureus Infection

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Journal Article